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CPNE7

Gene

3 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Biomedical Research Council and 7 more
  • 1 of 2 findings with company ties
  • Animals2

Effects

1

Dentin regeneration

upin mice1

1 study

  1. CPNE7 improves dentin regeneration in mice.

    “Furthermore, physiologic dentin was regenerated in artificial dentinal defects of Cpne7-overexpressing transgenic mice.”

    Animalsin artificial dentinal defects of Cpne7-overexpressing transgenic mice

    Cpne7 deficiency induces cellular senescence and premature aging of dental pulp

    Aging cell

Associations

1

Skin aging

downin humans1OR 0.905

1 study

  1. CPNE7 is associated with skin aging in humans (OR 0.905, 95% CI 0.852–0.958).

    “CPNE7: 0.905 [0.852-0.958]”

    Review

    Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes

    Journal of physiological anthropology

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