CNOT3

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funder: Basic and Applied Basic Research Foundation of Guangdong Province

Animals1

Effects

Stem cell differentiation

upin mouse cells1

1 study

CNOT3 activates stem cell differentiation in mouse cells.
“Cnot3 upregulated the expressions of pluripotent genes in mouse ESCs and promoted the differentiation of ESCs into PGCLCs in vitro.”
Cellsin vitro
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation
Stem cell research & therapy17 Jan 2026

Upstream

Ovarian aging

downin mice1downin pigs1

1 study

Ovarian aging decreases CNOT3 in mice.
“the expression of CNOT3 significantly decreased in aging ovaries of pigs and mice, compared with young ovaries.”
Animalsovary
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation
Stem cell research & therapy17 Jan 2026
Ovarian aging decreases CNOT3 in pigs.
“the expression of CNOT3 significantly decreased in aging ovaries of pigs and mice, compared with young ovaries.”
Animalsovary
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation
Stem cell research & therapy17 Jan 2026

Latest

1 in 12 months

Stem Cell Research & Therapy18 Jan

CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation

Experiments in miceReproductive system

Paper

CNOT3

Effects

Upstream

Latest

CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation

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