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CG12744

Gene

1 paper3 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 2 more
  • Model organisms1

Effects

3

Intestinal stem cell overproliferation

downin flies1

1 study

  1. CG12744 prevents intestinal stem cell overproliferation in flies.

    “Moreover, CG12744 prevented age-related intestinal stem cell (ISC) overproliferation and differentiation by modulating the EGFR, JNK, and BMP pathways.”

    Model organismsintestine

    The zinc finger protein CG12744 regulates intestinal stem cells in aged Drosophila through the EGFR and BMP pathways

    Life sciences2 Feb 2024

Gut hyperplasia

downin flies1

1 study

  1. CG12744 decreases gut hyperplasia in flies.

    “In contrast, the overexpression of CG12744 in progenitor cells restrained age-related gut hyperplasia in Drosophila.”

    Model organismsoverexpression in progenitor cellsgut

    The zinc finger protein CG12744 regulates intestinal stem cells in aged Drosophila through the EGFR and BMP pathways

    Life sciences2 Feb 2024

More on Gut hyperplasia

Intestinal hyperplasia

downin flies1

1 study

  1. CG12744 prevents intestinal hyperplasia in flies.

    “Knockdown of CG12744 in progenitor cells further exacerbates the age-related intestinal hyperplasia and dysfunction.”

    Model organismsknockdown in progenitor cellsintestine

    The zinc finger protein CG12744 regulates intestinal stem cells in aged Drosophila through the EGFR and BMP pathways

    Life sciences2 Feb 2024

More on Intestinal hyperplasia

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