There are 6 papers on BCAT2 in aging research: 1 trial and 1 observational study in people, 3 in animals.
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Japan Agency for Medical Research and Development and 6 more
- Human trial1
- Humans1
- Animals3
- In silico1
Effects
2B-cell lymphoma growth inhibition by α-ketoglutarate
is required forin mouse cells1
1 study
B-cell lymphoma growth inhibition by α-ketoglutarate
is required forin mouse cells1
BCAT2 is required for B-cell lymphoma growth inhibition by α-ketoglutarate in mouse cells (shown by deletion).
“blocking leucine catabolism through branched-chain amino acid transaminase 2 deletion, all blunted the antilymphoma effects of αKG”
Cellsshown by deletion
α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development
Blood
Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
BCAT2 induces cellular senescence in mice (reduction in BCAT2 levels).
“reduction in BCAT2 levels alone is sufficient to induce cellular senescence, both in cultured cells and in mice.”
Animalsreduction in BCAT2 levels
Branched-chain amino acid metabolism is a crucial modulator of cellular senescence
bioRxiv (Cold Spring Harbor Laboratory)Preprint