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ACSL5

Gene

3 papers study it3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: National Natural Science Foundation of China and 6 more
  • Animals3

Interventions

1

Caloric restriction

upin mice1

1 study

  1. Caloric restriction increases ACSL5 in mice.

    “Aldh2, Aldh3a2, and Aldh9a1 in carnitine biosynthesis and Acsl5 in carnitine shuttle system were up-regulated by increased CR”

    Animalsliver3 monthsmales

    The Effects of Graded Levels of Calorie Restriction: XIX. Impact of Graded Calorie Restriction on Protein Expression in the Liver

    The journals of gerontology. Series A, Biological sciences and medical sciencesJul 8, 2023

More on Caloric restriction

Effects

2

Cancer cell proliferation

downin human cells1

1 study

  1. ACSL5 inhibits cancer cell proliferation in human cells.

    “ACSL5 overexpression promoted BC senescence and inhibited BC cell proliferation”

    CellsACSL5 overexpression

    ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation

    OncogeneJul 1, 2025

Cellular senescence

upin human cells1

1 study

  1. ACSL5 induces cellular senescence in human cells.

    “ACSL5 overexpression promoted BC senescence and inhibited BC cell proliferation”

    CellsACSL5 overexpression

    ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation

    OncogeneJul 1, 2025

More on Cellular senescence

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