ABHD10

1. ABHD10 increases lipid droplet formation in mouse cells.

   “improved mitochondrial membrane potential, and lowered lipid droplet formation along with triglycerides and fatty acids.”

   CellsShown by ABHD10 silencing in senescent cells

   The ABHD10-KCMF1 Complex Mitigates Cochlear Aging by Regulating Mitochondrial Lipid Metabolism

   Journal of cellular physiology·1 May 2026

1. ABHD10 increases cellular senescence in mouse cells.

   “ABHD10 was upregulated in d-galactose-induced HEI-OC1 cells and aged mouse cochlear hair cells, where it promoted senescence.”

   Cellsd-galactose-induced cellsHEI-OC1

   The ABHD10-KCMF1 Complex Mitigates Cochlear Aging by Regulating Mitochondrial Lipid Metabolism

   Journal of cellular physiology·1 May 2026

More on Cellular senescence

1. ABHD10 lowers the risk of presbycusis in humans.

   “Genetically predicted higher ABHD10 expression was identified as a protective factor against presbycusis”

   HumansGenetically predicted higher expression; Mendelian randomization

   The ABHD10-KCMF1 Complex Mitigates Cochlear Aging by Regulating Mitochondrial Lipid Metabolism

   Journal of cellular physiology·1 May 2026

More on Presbycusis