There are 3 papers on ABCA6 in aging research: 3 observational studies in people.
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“A disease-causing mutation in ABCA6 is identified for FPD.”
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Humans3
Effects
2Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
ABCA6 inhibits cellular senescence in mouse cells (organoids from knockout mice).
“ABCA6 deficiency can lead to chondrocyte degeneration via modulating cell cycle and activating cellular senescence.”
Cellsorganoids from knockout mice
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Osteoarthritis
downin mice1
1 study
Osteoarthritis
downin mice1
ABCA6 protects against osteoarthritis in mice (knockout mice).
“ABCA6-KO mice demonstrate severe knee joint degeneration and accelerated OA progression.”
Animalsknockout miceknee joint
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Associations
1Patellar dysplasia
upin humans1
1 study
Patellar dysplasia
upin humans1
ABCA6 is associated with patellar dysplasia in humans (four-generation family with six cases).
“A disease-causing mutation in ABCA6 is identified for FPD.”
Humansfour-generation family with six cases
Advanced science (Weinheim, Baden-Wurttemberg, Germany)