Systemic autoimmunity

Human lymph node fibroblasts show cellular aging features before rheumatoid arthritis onset

Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.