Systemic autoimmunity and sialadenitis

Advancing age is associated with systemic autoimmunity and sialadenitis in mice.

“Our findings demonstrate that UM-HET3 mice naturally develop systemic autoimmunity and sialadenitis with age, with a clear female bias.”

AnimalsUM-HET3 miceboth; female biass

Aging-Associated Autoimmunity in Genetically Diverse UM-HET3 Mice Shows a Female Sex Bias

bioRxiv (Cold Spring Harbor Laboratory)·31 Jul 2025Preprint