Sinoatrial node dysfunction

1. Cellular senescence is associated with sinoatrial node dysfunction.

   “mechanisms underlying SND, including fibrosis, ion-channel and calcium-clock remodeling, mitochondrial dysfunction, cellular senescence, impaired β-adrenergic signaling, genetic susceptibility, and epigenetic or epitranscriptomic regulation.”

   Reviewaging-associated intrinsic sinoatrial node dysfunctionsinoatrial node

   Sinoatrial node dysfunction: molecular mechanisms, arrhythmogenesis, and translational pathways toward precision therapy

   Pharmacology & therapeutics·13 Oct 2026

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