3 papers3 findings
Frailty index
upin humans1HR 3.37
Frailty index raises the risk of severe infections in humans (HR 3.37 (95 % CI: 2.96 to 3.83)).
“Higher FI levels showed progressively greater risk, with HRs (95 % CIs) of 1.40 (1.38 to 1.43), 2.01 (1.96 to 2.06), 2.64 (2.53 to 2.76) and 3.37 (2.96 to 3.83)”
HumansFI ≥ 0.4 versus FI < 0.1
The Journal of frailty & aging11 Dec 2025
PhenoAge
upin humans1HR 1.27
PhenoAge raises the risk of severe infections in humans (HR: 1.27; 95 % CI: 1.25 to 1.29).
“PhenoAge acceleration (HR: 1.27; 95 % CI: 1.25 to 1.29) were associated with increased severe infection risk.”
Humans
The Journal of frailty & aging11 Dec 2025
Klemera-Doubal method biological age
upin humans1HR 1.18
Klemera-Doubal method biological age raises the risk of severe infections in humans (HR: 1.18; 95 % CI: 1.16 to 1.19).
“KDM-BA acceleration (HR: 1.18; 95 % CI: 1.16 to 1.19) and PhenoAge acceleration (HR: 1.27; 95 % CI: 1.25 to 1.29) were associated with increased severe infection risk.”
Humans
The Journal of frailty & aging11 Dec 2025
1 trialPhase 4360 people
Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk of future infection.Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk of future infection.