Overt hypothyroidism

1. Mean cell volume mediates overt hypothyroidism in humans (10% mediated).

   “Mediation analysis revealed that mean cell volume mediated 10% of the association between phenotypic age and overt hypothyroidism”

   Humansmediation of the association between phenotypic age and overt hypothyroidismn = 6,681

   Assessing thyroid health: phenotypic age compared to chronological age

   Frontiers in endocrinology·4 Jul 2025

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1. Age-gap is associated with overt hypothyroidism in humans.

   “Overt hypothyroidism demonstrated an inverted U-shaped association with both age metrics and a positive correlation with age gap.”

   Humansn = 6,681

   Assessing thyroid health: phenotypic age compared to chronological age

   Frontiers in endocrinology·4 Jul 2025

More on Age-gap