Non-small cell lung cancer progression

1 paper2 findings

Animals1

Interventions

1

PAR1 inhibitor

downin human cells1

1 study

PAR1 inhibitor decreases non-small cell lung cancer progression in human cells.
“Knocking down MMP1 or using PAR1 inhibitors reduced the tumor-promoting effects of DHLF-derived exosomes in vivo and in vitro.”
Cellsin vivo and in vitro
Senescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1
Oncogene11 Dec 2024

More on PAR1 inhibitor

Upstream

1

MMP1

upin human cells1

1 study

MMP1 increases non-small cell lung cancer progression in human cells.
“Knocking down MMP1 or using PAR1 inhibitors reduced the tumor-promoting effects of DHLF-derived exosomes in vivo and in vitro.”
Cellsin vivo and in vitro
Senescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1
Oncogene11 Dec 2024

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Study in peopleCellular senescence

Oncogene12 Dec

Senescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1

Experiments in miceCellular senescence