Mild cognitive impairment or Alzheimer disease

Disease

1 paper1 finding

Humans1

Associations

APOE

upin humans1HR 1.81

1 study

APOE raises the risk of mild cognitive impairment or Alzheimer disease in humans (HR = 1.81).
“Among controls, male and female carriers were more likely to convert to MCI/AD, but the effect was stronger in women (HR = 1.81 for women; HR = 1.27 for men; interaction: p = 0.011).”
Humansin controlsfemales
Sex modifies the APOE-related risk of developing Alzheimer disease
Annals of neurology14 Apr 2014

Latest

4 in 12 months

Neurology Open Access4 Oct

Epigenetic age links to higher dementia risk in older adults

In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).

Cohort study of 2,606 peopleAll-cause dementia

Paper

JAMA Network Open18 Sep