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Pineal gland-derived polypeptide factors

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

Outcomes

1

Lifespan

upin mice1

1 study

  1. Pineal gland-derived polypeptide factors extend lifespan in mice (+20% in young, +17% in middle-aged).

    “PF treatment increased life span of both young and middle-aged mice by 20% and 17%, respectively”

    Animalspolypeptide factors0.1 mgfemales

    Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age

    Mechanisms of ageing and development1 Sep 1989

Associations

1

Mammary adenocarcinoma

downin mice1

1 study

  1. Pineal gland-derived polypeptide factors lower the risk of mammary adenocarcinoma in mice (2.6-fold decrease).

    “Both factors when administered to young mice caused a decrease in both overall tumour incidence and incidence of mammary adenocarcinomas (TF, 1.8-fold decrease; PF, 2.6-fold decrease).”

    Animalspolypeptide factors0.1 mgfemales

    Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age

    Mechanisms of ageing and development1 Sep 1989

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