Ischemic stroke/systemic embolism

1. Klemera-Doubal biological age predicts ischemic stroke/systemic embolism in humans (Adjusted HR 1.96 (95% CI 1.37–2.78)).

   “composite outcomes, death, major bleeding, SSE, and heart failure were 2.11 (1.82-2.45), 2.53 (2.06-3.11), 2.12 (1.60-2.83), 1.96 (1.37-2.78), and 1.83 (1.42-2.38), respectively”

   HumansPatients with atrial fibrillation; quartile 4 KDM biological age; adjusted analysisMedian 35.9 monthsBoth; 1424 (41.8%) femalesn = 3,405

   Impact of biological age versus chronological age on clinical outcomes in patients with atrial fibrillation: insights from the COOL-AF registry

   Journal of thrombosis and thrombolysis·12 Jan 2026

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