PLOS Digital Health
Higher strain across body systems linked to lung cancer
The lung cancer hazard ratio—a comparison of diagnosis rates over time—was 1.629 for participants with high versus normal strain across body systems.The lung cancer hazard ratio—a comparison of diagnosis rates over time—was 1.629 for participants with high versus normal strain across body systems.
Cohort · 336,945 peopleLung cancer
Who was studied336,945 UK Biobank participants, median 13.79 years
What changedLung cancer risk was 7.3% higher for each one-unit increase in multisystem physiological strain
The catchSmoking burden could confound the association; detailed smoking adjustment weakened it