What does the research say about lower extremity peripheral artery disease?

Lower extremity peripheral artery disease

There are 6 papers on lower extremity peripheral artery disease in aging research: 1 trial and 2 observational studies in people, 1 review. The newest story, Nov 7, 2026: “Perceived walking gains did not always match leg symptom changes”.

Disease

6 papers study it37 more mention it2 findings

6 new papers in 30 daysSee all 43 papers on lower extremity peripheral artery disease

“The DALY rate likewise increased from 2.20 to 2.75 per 100,000 population, a 25.4% increase, with an EAPC of 0.69% per year.”

High Fasting Plasma Glucose and the Rising Midlife Burden of Lower-Extremity Peripheral Artery Disease, 1990-2023AHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.14438

Human trial1
Humans2
In silico2

Effects

Mortality rate

upin humans1

1 study

Lower extremity peripheral artery disease is linked with higher mortality rate in humans (0.054 to 0.064 deaths per 100,000 population; 579 to 1,404 deaths).
“Deaths climbed from 579 to 1,404, and the death rate increased from 0.054 to 0.064 per 100,000 population.”
HumansGlobal lower-extremity peripheral artery disease attributable to high fasting plasma glucose; temporal comparison1990–2023
High Fasting Plasma Glucose and the Rising Midlife Burden of Lower-Extremity Peripheral Artery Disease, 1990-2023
AHA Scientific Sessions 2026 abstractNov 2, 2026

Disability-adjusted life-year rate

upin humans1

1 study

Lower extremity peripheral artery disease is linked with higher disability-adjusted life-year rate in humans (+25.4%; 2.20 to 2.75 per 100,000 population; EAPC 0.69% per year).
“The DALY rate likewise increased from 2.20 to 2.75 per 100,000 population, a 25.4% increase, with an EAPC of 0.69% per year.”
HumansGlobal lower-extremity peripheral artery disease attributable to high fasting plasma glucose; temporal comparison1990–2023
High Fasting Plasma Glucose and the Rising Midlife Burden of Lower-Extremity Peripheral Artery Disease, 1990-2023
AHA Scientific Sessions 2026 abstractNov 2, 2026

Funding

1 grant since 2025

Japan Society for the Promotion of Science¥4.6M

Construction of a novel remote EMS intervention model for lower-extremity peripheral artery disease with sarcopenia
Japan Society for the Promotion of ScienceToyohashi SOZO University¥4.6M2025–2029

Latest

22 papers in 12 months

AHA Scientific Sessions 2026 AbstractNov 7

Perceived walking gains did not always match leg symptom changes

Across five trials, perceived walking-distance scores rose 10.01 points with exercise versus 3.10 with control over six months.Across five trials, perceived walking-distance scores rose 10.01 points with exercise versus 3.10 with control over six months.

Meta-analysis · 626 peopleInterventions