Kidney failure requiring replacement therapy

1. C-reactive protein is associated with kidney failure requiring replacement therapy in humans (HR 1.09 (95% CI 1.02-1.15); 6,177 events).

   “1.09 (1.02-1.15) for KFRT (n=6,177)”

   HumansCKD stages 3-5; hsCRP ≥2 mg/L; associations inconsistent across CKD stagesMedian 3.9 years65% malesn = 23,008

   High sensitivity C-reactive protein and the risk of cardio-kidney outcomes in adults with moderate to severe chronic kidney disease: a nationwide study

   Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·16 Oct 2026

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