The Lancet Healthy Longevity
High-dose flu vaccine may help more as frailty risk rises
Against standard-dose vaccine, estimated relative effectiveness against flu or pneumonia hospitalization was 0.2%, 13.1% and 19.9% at low, intermediate and high frailty…Against standard-dose vaccine, estimated relative effectiveness against flu or pneumonia hospitalization was 0.2%, 13.1% and 19.9% at low, intermediate and high frailty risk.

Randomized trial · 332,438 peopleInterventions
Who was studied332,438 adults aged 65 or older
What changedEstimated reductions in flu or pneumonia hospitalization with high-dose versus standard-dose vaccine rose from 0.2% to 19.9% across increasing frailty risk
The catchSanofi funded the trial
