Sjögren disease

1. Sjögren disease increases CD11b+ CD95+ CD19+ age-associated B cells in mice.

   “ABCs (CD11b+ CD95+ CD19+) began locally accumulating in the SGs from the mature-adult stage, earlier than in age-matched controls”

   AnimalsSjögren disease modelsalivary glands

   Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease

   Journal of immunology research·1 Jan 2026

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1. Sjögren disease is associated with T-bet+ CD20+ age-associated B cells in humans.

   “T-bet+ CD20+ ABCs were detected infiltrating the glands in SjD patients, especially in individuals in their 40s-60s, but were rare in non-SjD sicca controls.”

   HumansSjögren diseaselabial salivary glands

   Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease

   Journal of immunology research·1 Jan 2026

More on T-bet+ CD20+ age-associated B cells