Hypomagnesemia

Hypomagnesemia decreases brain volumes in humans (pinteraction < .05).

“In participants with diabetes, hypomagnesemia was associated with lower volumes of multiple brain regions, which were not observed in participants without diabetes (pinteraction < .05).”

Humansin participants with diabetes

Associations of serum magnesium and magnesium intake with brain morphology and cognitive function in Puerto Rican adults

The journals of gerontology. Series A, Biological sciences and medical sciences·5 Nov 2025

Hypomagnesemia impairs global cognitive function in humans (β = -0.058, 95% CI -0.11 to -0.0020).

“hypomagnesemia was not associated with brain MRI measures, but with global cognitive function [β (95% CI) = -0.058 (-0.11, -0.0020)], in fully adjusted models”

Humansn = 1,049

Associations of serum magnesium and magnesium intake with brain morphology and cognitive function in Puerto Rican adults

The journals of gerontology. Series A, Biological sciences and medical sciences·5 Nov 2025