Hematopoietic neoplasms

Disease

4 papers2 findings

Animals4

Associations

Amifostine

downin mice1

1 study

Amifostine lowers the risk of hematopoietic neoplasms in mice (1.8-fold lower vs 5.4 Gy).
“Amifostine treatment did protect against radiation-induced hematopoietic tumors, while protection against solid neoplasms was significant but incomplete.”
Animalsin mice pretreated before 10.8 Gy total-body irradiation compared to 5.4 Gy TBI alone
Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine
Radiation research12 Mar 2018

Trial sponsors

University of Sao Paulo
1 trialPhase 1/247 people
University of Sao Paulo General Hospital
1 trialPhase 1/247 people
National Cancer Institute
1 trialPhase 186 people

Latest

3 in 12 months

Nature Communications14 Oct

TET2 loss alters DNA copying during drug treatment in cells

Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.

Experiments in laboratory-grown cells, against cells lacking DNMT3ATET2

Limit: The proposed sequence from damaged DNA sites to breaks remains a theoretical model

Paper

Cancers15 Sep