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Broad-spectrum antibiotics

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Center for Cancer Research and 3 more
  • Animals1

Outcomes

2

Lifespan

no changein mice1downin mice1

1 study

  1. Broad-spectrum antibiotics have no effect on lifespan in mice.

    “when Ab were administered one month after TBI, lifespan was unchanged compared to the control TBI group”

    Animalsadministered one month after 3 Gy TBI6 weeks

    The effect of modulation of gut microbiome profile on radiation-induced carcinogenesis and survival

    Journal of radiation research20 Jan 2023

  2. Broad-spectrum antibiotics shorten lifespan in mice.

    “shortened the lifespan when Ab were administered before and after TBI”

    Animalsadministered 3 weeks before and 3 weeks after 3 Gy TBI6 weeks total

    The effect of modulation of gut microbiome profile on radiation-induced carcinogenesis and survival

    Journal of radiation research20 Jan 2023

Time to solid tumor appearance

downin mice1

1 study

  1. Broad-spectrum antibiotics decrease time to solid tumor appearance in mice.

    “decrease in the time in which solid tumors started to appear”

    Animalsadministered before and after TBI

    The effect of modulation of gut microbiome profile on radiation-induced carcinogenesis and survival

    Journal of radiation research20 Jan 2023

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