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Amifostine

Intervention

1 paper2 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 3 more
  • 2 of 2 findings with company ties
  • Animals1

Associations

2

Solid neoplasm

upin mice1

1 study

  1. Amifostine raises the risk of solid neoplasm in mice (1.6-fold).

    “Solid tumor incidence was greater in the 10.8 Gy/Amifostine group (1.6-fold).”

    Animalsin mice pretreated before 10.8 Gy total-body irradiation compared to 5.4 Gy TBI alone

    Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine

    Radiation research12 Mar 2018

More on Solid neoplasm

Hematopoietic neoplasms

downin mice1

1 study

  1. Amifostine lowers the risk of hematopoietic neoplasms in mice (1.8-fold lower vs 5.4 Gy).

    “Amifostine treatment did protect against radiation-induced hematopoietic tumors, while protection against solid neoplasms was significant but incomplete.”

    Animalsin mice pretreated before 10.8 Gy total-body irradiation compared to 5.4 Gy TBI alone

    Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine

    Radiation research12 Mar 2018

More on Hematopoietic neoplasms

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