Familial melanoma syndrome

1. Familial melanoma syndrome is associated with SASP secretion in human cells.

   “Patient derived fibroblasts also secreted less SASP than control cells.”

   CellsPatient-derived fibroblasts compared with control cellsskin fibroblast

   Multiple outcomes of the germline p16INK4a mutation affecting senescence and immunity in human skin

   Aging cell·17 Oct 2024

More on SASP secretion

1. Familial melanoma syndrome is associated with fibroblast replicative capacity in human cells.

   “fibroblasts isolated from the skin of patients have increased replicative capacity compared to control fibroblasts in vitro, culminating in abnormal nuclear morphology.”

   CellsPatient-derived fibroblasts compared with control fibroblastsskin fibroblast

   Multiple outcomes of the germline p16INK4a mutation affecting senescence and immunity in human skin

   Aging cell·17 Oct 2024