Elderly-onset rheumatoid arthritis

1. Elderly-onset rheumatoid arthritis increases joint destruction in humans.

   “EORA follows a more aggressive course with severe joint destruction and significant comorbidities.”

   Reviewelderly-onset rheumatoid arthritis

   Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment

   Current opinion in immunology·13 Jan 2026

1. Inflammation induces elderly-onset rheumatoid arthritis.

   “EORA is not merely late-onset RA but a pathogenically unique entity, driven by immune aging, inflammaging, and other mechanisms like defective immunosuppressive system, age-related somatic mosaicism, and dysbiosis.”

   Reviewelderly-onset rheumatoid arthritis

   Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment

   Current opinion in immunology·13 Jan 2026

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