Chronic Graft Versus Host Disease

1. Chronic Graft Versus Host Disease increases oxidative stress and ROS signaling in mice.

   “Upregulation of 8-OHdG and 4HNE, along with downregulation of catalase and Nrf2, was observed, indicating enhanced oxidative stress”

   Animalsin murine cGVHD modelcornea

   Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

   BMC ophthalmology·Jul 1, 2025

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1. Chronic Graft Versus Host Disease increases cellular senescence in mice.

   “Elevated levels of pro-inflammatory markers (IL-6, IL-8, NF-κB), the pro-fibrotic marker α-SMA, and senescence markers (P16INK4A, P38 MARK) were detected.”

   Animalsin murine cGVHD modelcornea

   Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

   BMC ophthalmology·Jul 1, 2025

More on Cellular senescence

1. Chronic Graft Versus Host Disease increases inflammation in mice.

   “Histological analysis showed significant inflammation and fibrosis in Meibomian glands (MGs) and lacrimal glands (LGs).”

   Animalsin murine cGVHD modelocular tissue

   Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

   BMC ophthalmology·Jul 1, 2025

More on Inflammation

1. Chronic Graft Versus Host Disease increases corneal epithelial damage in mice.

   “They also exhibited reduced tear volume and exacerbated corneal epithelial damage.”

   Animalsin murine cGVHD modelcornea

   Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

   BMC ophthalmology·Jul 1, 2025

1. Chronic Graft Versus Host Disease decreases tear volume in mice.

   “They also exhibited reduced tear volume and exacerbated corneal epithelial damage.”

   Animalsin murine cGVHD modelcornea

   Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

   BMC ophthalmology·Jul 1, 2025

More on Tear volume

1. Clonal hematopoiesis of indeterminate potential has no effect on Chronic Graft Versus Host Disease in humans.

   “There were no statistically significant differences in the cumulative incidence of cGVHD or any secondary outcomes by donor CH status.”

   Humansmyeloid malignancies undergoing RIC HCT

   Pilot Study of Donor-Engrafted Clonal Hematopoiesis Evolution and Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation Recipients Using a National Registry

   Transplantation and cellular therapy·Jul 28, 2023

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1. DNMT3A lowers the risk of Chronic Graft Versus Host Disease in humans (34.4% versus 57%).

   “the incidence of cGVHD was lower in recipients of grafts from DNMT3A CH+ donors versus donors without DNMT3A CH (34.4% versus 57%; P = .035).”

   Humansmyeloid malignancies undergoing RIC HCT

   Pilot Study of Donor-Engrafted Clonal Hematopoiesis Evolution and Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation Recipients Using a National Registry

   Transplantation and cellular therapy·Jul 28, 2023

More on DNMT3A