CONUT score

Biomarker

38 papers study it79 more mention it37 findings

4 new papers in 30 daysSee all 117

  • Human trial1
  • Humans36

Effects

4

Handgrip strength

downin humans1

1 study
  1. CONUT score decreases handgrip strength in humans (β = -1.5, 95% CI -1.7 to -1.3, r = -0.73, P < 0.001).

    “the CONUT score was significantly associated with HGS (β = -1.5; 95% CI, -1.7 to -1.3)”

    Humansfemalesn = 342

    Association of the Controlling Nutritional Status score with handgrip strength in postmenopausal women

    Menopause (New York, N.Y.)

In-hospital mortality

no changein humans1

1 study
  1. CONUT score has no effect on in-hospital mortality in humans.

    “In-hospital mortality was higher in frail compared to not-frail patients, but it did not differ between frail patients with high CONUT scores and frail patients with low CONUT scores.”

    Humansin frail hospitalized patientsn = 246

    Controlling Nutritional Status (CONUT) Score as a Predictive Marker in Hospitalized Frail Elderly Patients

    Journal of personalized medicine

Readmission due to heart failure

no changein humans1

1 study
  1. CONUT score has no effect on readmission due to heart failure in humans.

    “On multivariate logistic analysis, CONUT was not associated with readmission due to HF within 1 year.”

    Humansheart failure with preserved ejection fraction and coronary artery disease1 yearn = 371

    Prognostic significance of controlling nutritional status in older adults with heart failure with preserved ejection fraction: a prospective comparative study with other objective nutritional indices

    Aging clinical and experimental research

Hospital costs

no changein humans1

1 study
  1. CONUT score has no effect on hospital costs in humans.

    “hospital costs were not significantly higher.”

    Humanshospitalizedn = 11,795

    Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

    Frontiers in nutrition

Associations

19

Mortality

upin humans11+16% risk increaseHR 1.11–2.67

11 studies
  1. CONUT score predicts mortality in humans (adjusted HR = 2.62, 95% CI: 1.69-4.08, P < 0.001).

    “Patients with a high CONUT score (≥5) had a significantly higher risk of 3-year all-cause mortality compared to those with lower scores”

    HumansAECOPD3 yearsn = 931

    Association between controlling nutritional status (CONUT) and all-cause mortality in elderly hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study

    Frontiers in nutrition

  2. CONUT score raises the risk of mortality in humans (HR = 1.219, 95% CI: 1.190-1.250).

    “Each one-point increase in CONUT score nearly doubled the risk of death (HR = 1.219, 95% CI: 1.190-1.250, p < 0.001).”

    Humans

    Prognostic Value of the CONUT Score in Predicting All-Cause Mortality in Hospitalized Internal Medicine Patients: A Retrospective Cohort Study

    Journal of clinical medicine

  3. CONUT score raises the risk of mortality in humans (adjusted HR 1.11 (95% CI 1.03-1.19); p = 0.006).

    “higher CONUT scores were associated with increased mortality risk [continuous CONUT score: adjusted HR 1.11 (95% CI 1.03-1.19); p = 0.006]”

    Humansdysphagian = 235

    Correlation between controlling nutritional status score and mortality risk in older Japanese adults diagnosed with dysphagia: a retrospective cohort study

    Frontiers in nutrition

  4. CONUT score predicts mortality in humans (HR 1.18, 95% CI: 1.09-1.29).

    “Elevated continuous CONUT was related to higher all-cause (HR = 1.18, 95% CI: 1.09-1.29, P < 0.001) and cardiovascular mortality (HR = 1.26, 95% CI: 1.12-1.42, P < 0.001) in HF patients with diabetes.”

    Humansheart failure with diabetes5.6 [2.8-9.7] yearsn = 1,500

    Assessing the link of malnutrition with diabetes and mortality risk in heart failure patients

    ESC heart failure

  5. CONUT score predicts mortality in humans (HR = 2.67, 95%CI 1.34-5.33 and HR = 3.98, 95% CI: 1.77-8.97).

    “participants with CONUT-derived moderate to high risk of malnutrition had shorter survival (HR = 2.67, 95%CI 1.34-5.33 and HR = 3.98, 95% CI: 1.77-8.97, respectively)”

    Humansmoderate to high risk of malnutrition36 monthsn = 382

    Controlling nutritional status score and geriatric nutritional risk index as a predictor of mortality and hospitalization risk in hospitalized older adults

    Nutrition (Burbank, Los Angeles County, Calif.)

  6. CONUT score predicts mortality in humans (HR 1.50, 95% CI 1.18-1.91).

    “and overall mortality (HR: 1.50, 95%CI: 1.18-1.91).”

    Humansin COPD patientsn = 1,501

    Controlling nutritional status score in the prediction of cardiovascular disease prevalence, all-cause and cardiovascular mortality in chronic obstructive pulmonary disease population: NHANES 1999-2018

    BMC pulmonary medicine

  7. CONUT score raises the risk of mortality in humans (HR 2.322, 95% CI 1.236-4.359, P = 0.009).

    “2.322(1.236, 4.359), P = 0.009, respectively).”

    Humanship fracture1 yearn = 303

    The combined effect of controlling nutritional status increase and activities of daily living impairment on 12-month mortality of older adults after hip fracture: a retrospective cohort study

    Research SquarePreprint

  8. CONUT score predicts mortality in humans (AUC 0.789).

    “CONUT showed the best area under the curve value (0.789) for the prediction of all-cause mortality compared with the other objective nutritional indices.”

    Humansheart failure with preserved ejection fraction and coronary artery disease1 yearn = 371

    Prognostic significance of controlling nutritional status in older adults with heart failure with preserved ejection fraction: a prospective comparative study with other objective nutritional indices

    Aging clinical and experimental research

  9. CONUT score is associated with mortality in humans (HR 1.764 (95% CI 1.503, 2.071)).

    “CONUT was significantly associated with all-cause mortality independently of GNRI or PNI, after adjustment for major confounders”

    Humansheart failure with preserved ejection fraction and coronary artery disease1 yearn = 371

    Prognostic significance of controlling nutritional status in older adults with heart failure with preserved ejection fraction: a prospective comparative study with other objective nutritional indices

    Aging clinical and experimental research

  10. CONUT score predicts mortality in humans (HR 1.422, 95% CI 1.232 to 1.643, p<0.001).

    “The HR of CONUT scores adjusted by age, sex and other confounding variables was 1.422 (95% CI 1.232 to 1.643, p<0.001).”

    Humanscancer-free older patients receiving home medical care47.4% malessn = 625

    Impact of the Controlling Nutritional Status (CONUT) score as a prognostic factor for all-cause mortality in older patients without cancer receiving home medical care: hospital ward-based observational cohort study

    BMJ open

All 12

Sarcopenia

upin humans2OR 1.4–1.814

2 studies
  1. CONUT score raises the risk of sarcopenia in humans (OR 1.814, 95% CI 1.019-3.255).

    “Multivariate logistic regression analysis showed that a high CONUT score was an independent risk factor for sarcopenia (OR:1.814, 95% CI: 1.019-3.255, p = 0.044).”

    Humanshospitalized patientsn = 236

    Higher Controlling Nutritional Status (CONUT) score indicates increased risk of sarcopenia in elderly hospitalized patients: a single institution study in China

    Frontiers in nutrition

  2. CONUT score is associated with sarcopenia in humans (OR 1.40, 95% CI 1.18-1.66).

    “CONUT (OR 1.40, 95% CI 1.18 ~ 1.66)”

    Humansin AAA patientsn = 232

    The association between nutritional assessment tools and CT-assessed sarcopenia in abdominal aortic aneurysm: a cross-sectional study

    Frontiers in nutrition

More on Sarcopenia

Cardiovascular mortality

upin humans2HR 1.26–1.86

2 studies
  1. CONUT score predicts cardiovascular mortality in humans (HR 1.26, 95% CI: 1.12-1.42).

    “cardiovascular mortality (HR = 1.26, 95% CI: 1.12-1.42, P < 0.001) in HF patients with diabetes.”

    Humansheart failure with diabetes5.6 [2.8-9.7] yearsn = 1,500

    Assessing the link of malnutrition with diabetes and mortality risk in heart failure patients

    ESC heart failure

  2. CONUT score predicts cardiovascular mortality in humans (HR 1.86, 95% CI 1.27-2.74).

    “The CONUT score demonstrated a significant correlation with a heightened risk of CVD mortality (HR: 1.86, 95%CI: 1.27-2.74)”

    Humansin COPD patientsn = 1,501

    Controlling nutritional status score in the prediction of cardiovascular disease prevalence, all-cause and cardiovascular mortality in chronic obstructive pulmonary disease population: NHANES 1999-2018

    BMC pulmonary medicine

Cerebrovascular stenosis

upin humans1OR 2.15

1 study
  1. CONUT score predicts cerebrovascular stenosis in humans (AUC = 0.794, sensitivity 82.3%, specificity 76.1%).

    “The score demonstrated moderate diagnostic accuracy (AUC = 0.794)”

    Humansn = 1,057

    The relationship between controlling nutritional status (CONUT) and cerebrovascular stenosis: a retrospective study with implications for ischemic stroke prevention

    PeerJ

  2. CONUT score raises the risk of cerebrovascular stenosis in humans (OR = 2.15, 95% CI [1.89-2.47], p < 0.001).

    “Each 1-point CONUT increase elevated stenosis risk by 115% (OR = 2.15, 95% CI [1.89-2.47], p < 0.001)”

    Humansn = 1,057

    The relationship between controlling nutritional status (CONUT) and cerebrovascular stenosis: a retrospective study with implications for ischemic stroke prevention

    PeerJ

More on Cerebrovascular stenosis

Cerebrovascular stenosis severity

upin humans1

1 study
  1. CONUT score predicts cerebrovascular stenosis severity in humans (Spearman's ρ = 0.68, p < 0.001).

    “correlated with stenosis severity (Spearman's ρ = 0.68, p < 0.001)”

    Humansn = 1,057

    The relationship between controlling nutritional status (CONUT) and cerebrovascular stenosis: a retrospective study with implications for ischemic stroke prevention

    PeerJ

Cognitive impairment

upin humans1OR 1.133

1 study
  1. CONUT score is associated with cognitive impairment in humans (OR 1.133 (95% CI: 1.052, 1.221; P = 0.002)).

    “According to the adjusted logistic regression analysis, the CONUT score was associated with cognitive impairment (OR: 1.133, 95% CI: 1.052, 1.221; P = 0.002).”

    Humans

    Associations between nutritional status and cognitive impairment in older adults: results from the NHANES 2011-2014 cycles

    Frontiers in nutrition

More on Cognitive impairment

Urban quality

upin humans1

1 study
  1. Urban quality is associated with CONUT score in humans (Spearman R=0.2513, p=0.0359).

    “CONUT scores (p=0.0323), which were positive correlated with urban quality (Spearman R=0.2513, p=0.0359)”

    Humans

    Exploring the Influence of Urban Quality on Frailty, Nutritional Status, and Hematological/Biochemical Profile in Older Adults: Insights from Geospatial Approach (Preprint)

    Preprint

More on Urban quality

Diabetes

upin humans1OR 1.19

1 study
  1. CONUT score is associated with diabetes in humans (OR 1.19, 95% CI: 1.08-1.32).

    “Continuous CONUT was significantly associated with diabetes in HF (OR 1.19, 95% CI: 1.08-1.32, P < 0.001)”

    Humansheart failuren = 1,501

    Assessing the link of malnutrition with diabetes and mortality risk in heart failure patients

    ESC heart failure

More on Diabetes

Hospitalization

upin humans1HR 1.91

1 study
  1. CONUT score predicts hospitalization in humans (HR = 1.91; 95% CI: 1.03-3.55 and HR = 1.98; 95% CI: 1.14-3.42).

    “as well as shorter survival free of urgent hospitalization (HR = 1.91; 95% CI: 1.03-3.55 and HR = 1.98; 95% CI: 1.14-3.42, respectively)”

    Humansmoderate to high risk of malnutrition36 monthsn = 382

    Controlling nutritional status score and geriatric nutritional risk index as a predictor of mortality and hospitalization risk in hospitalized older adults

    Nutrition (Burbank, Los Angeles County, Calif.)

Cardiovascular disease

upin humans1OR 1.86

1 study
  1. CONUT score is associated with cardiovascular disease in humans (OR 1.86, 95% CI 1.28-2.70).

    “Logistic analyses suggested a distinct connection between the CONUT score and CVD prevalence (OR:1.86, 95%CI:1.28-2.70) in individuals with COPD.”

    Humansin individuals with COPDn = 1,501

    Controlling nutritional status score in the prediction of cardiovascular disease prevalence, all-cause and cardiovascular mortality in chronic obstructive pulmonary disease population: NHANES 1999-2018

    BMC pulmonary medicine

More on Cardiovascular disease

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