Amyotrophic lateral sclerosis with frontotemporal dementia

Papers on amyotrophic lateral sclerosis with frontotemporal dementia

31 papers1 new in 30 days

Wednesday, October 7

medRxivOct 7

Links between age and blood DNA repeats differ by disease

An observational preprint analyzed blood from 54 people carrying expanded DNA repeats, including people with amyotrophic lateral sclerosis, frontotemporal dementia or no…An observational preprint analyzed blood from 54 people carrying expanded DNA repeats, including people with amyotrophic lateral sclerosis, frontotemporal dementia or no symptoms.

Optical Genome Mapping (OGM) to size the G4C2 pathological repeat in C9orf72.

Preprint: cross-sectional study of 54 peopleMechanisms

Friday, July 3

Frontiers in NeurologyJul 3

A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders

ReviewInflammation

Thursday, July 2

CellJul 2

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders

Case-control study of 469 peopleMechanisms

Saturday, May 30

The EMBO JournalMay 30

The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair

Experiments in miceC9ORF72

Saturday, April 11

Ageing Research ReviewsApr 11

Mechanistic research and therapeutic prospects of alternative splicing in neurodegenerative diseases

ReviewRNA splicing

Monday, March 30

Molecular Therapy Nucleic AcidsMar 30

Exosome-like nanovesicles from acerola for CRISPR-Cas9 ribonucleoprotein delivery to the central nervous system

Experiments in animalsInterventions

Monday, January 12

BMB ReportsJan 12

Stress granules as a central hub linking organelle stress, aging, and neurodegeneration

ReviewMechanisms

Saturday, November 22

Nature CommunicationsNov 22

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

Experiments in miceMechanisms

Thursday, October 30

Annals of NeurologyOct 30

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Cohort study of 2,695 peopleFrontotemporal dementia

Monday, September 1

Journal of NeuroendocrinologySep 1

Sleep in neurodegenerative diseases: A focus on melatonin, melanin-concentrating hormone and orexin

ReviewMechanisms

Sunday, December 15

International Journal of Molecular SciencesDec 15

Artificial Intelligence-Assisted Comparative Analysis of the Overlapping Molecular Pathophysiology of Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

Computational studyMechanisms

Saturday, December 14

International Journal of Molecular SciencesDec 14

The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegenerative Diseases

ReviewNeurodegenerative disease

Saturday, November 2

Annals of NeurologyNov 2

Longitudinal Magnetic Resonance Imaging in Asymptomatic C9orf72 Mutation Carriers Distinguishes Phenoconverters to Amyotrophic Lateral Sclerosis or Amyotrophic Lateral Sclerosis With Frontotemporal Dementia

Cohort study of 359 peopleFrontotemporal dementia

Monday, October 28

bioRxivOct 28

Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease

Preprint: study in peopleMechanisms

Monday, September 30

Molecular NeurobiologySep 30

Identification of Potential Causal Genes for Neurodegenerative Diseases by Mitochondria-Related Genome-Wide Mendelian Randomization

Computational studyMitochondrion

Tuesday, September 24

BMJ Neurology OpenSep 24

Personalised penetrance estimation for C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia

Computational studyFrontotemporal dementia

Monday, September 9

Nucleic Acids ResearchSep 9

Stress granule formation helps to mitigate neurodegeneration

Experiments in fliesMechanisms

Wednesday, September 4

Journal of NeurologySep 4

Apolipoproteins, lipids, lipid-lowering drugs and risk of amyotrophic lateral sclerosis and frontotemporal dementia: a meta-analysis and Mendelian randomisation study

Study in peopleFrontotemporal dementia

Wednesday, August 28

Pharmacological ResearchAug 28

Metformin: From diabetes to cancer to prolongation of life

ReviewMetformin

Monday, December 11

bioRxivDec 11

Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations

Preprint: case-control study of 404 peopleMechanisms

Tuesday, November 21

bioRxivNov 21

Stress granule formation helps to mitigate neurodegeneration

Preprint: experiments in fliesMechanisms

Monday, September 25

PLOS GeneticsSep 25

TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1

Experiments in fliesMechanisms

Sunday, March 12

CellsMar 12

Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders

ReviewOxidative stress and ROS signaling

Friday, December 2

PNASDec 2

Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease

Experiments in miceInterventions

Tuesday, July 12

Frontiers in NeuroscienceJul 12

Astrocytes in Neurodegeneration: Inspiration From Genetics

ReviewMechanisms

Saturday, January 22

AntioxidantsJan 22

Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

Experiments in fliesInterventions

Wednesday, February 10

BMC Research NotesFeb 10

Inhibition of Ref(2)P, the Drosophila homologue of the p62/SQSTM1 gene, increases lifespan and leads to a decline in motor function

Experiments in fliesMechanisms

Wednesday, January 1

Brain CommunicationsJan 1

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice

Experiments in miceInflammation

Wednesday, December 18

Acta Neuropathologica CommunicationsDec 18

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

Experiments in fliesMechanisms

Wednesday, April 26

Acta NeuropathologicaApr 26

DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients

Cross-sectional study of 46 peopleEpigenetic age