Age-induced obesity

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Animals1

Upstream

1

NAMPT

upin mice1

1 study

NAMPT increases age-induced obesity in mice.
“adipocyte-specific Nampt deletion protected against age-induced obesity without changing energy balance.”
Animalsshown by adipocyte-specific Nampt deletion during agingadipocytefemales
Adipocyte-specific inactivation of NAMPT, a key NAD⁺ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging
American journal of physiology. Endocrinology and metabolismMay 29, 2024

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American Journal of Physiology Endocrinology and MetabolismMay 29

Adipocyte-specific inactivation of NAMPT, a key NAD⁺ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging

Experiments in miceNAD+ metabolism

PNAS NexusMar 1

Store-operated Ca²⁺ entry regulatory factor alters murine metabolic state in an age-dependent manner via hypothalamic pathways

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Store-operated Ca 2+ entry regulatory factor (SARAF) alters murine metabolic state age-dependent via hypothalamic pathways

Preprint: experiments in miceOxidative phosphorylation

International Journal of Biological SciencesApr 20

Aurka deficiency in the intestinal epithelium promotes age-induced obesity via propionate-mediated AKT activation

Experiments in animalsMechanisms

bioRxivJul 31

Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice

Preprint: experiments in animalsMechanisms

Aging CellJun 17

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

Experiments in miceDietary restriction