X-chromosome inactivation skewing

1. Clonal hematopoiesis driver mutations are associated with X-chromosome inactivation skewing in humans.

   “Mutational burden of both genes correlated with X-inactivation skewing”

   Humansn = 2,530

   DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

   Blood·27 Jun 2017

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