Association of Moderate‐to‐Severe Chronic Pain with Cognitive Decline and Alzheimer's Biomarkers in the Alzheimer's Disease Neuroimaging Initiative

Abstract

Background: Chronic pain affects one in five older adults and is linked to increased risk for Alzheimer's disease (AD) dementia. Few studies have investigated associations between chronic pain and AD biomarkers, especially chronic pain at moderate‐to‐severe levels considered clinically significant.