What does the research say about white matter hyperintensity severity?

White matter hyperintensity severity

There are 4 papers on white matter hyperintensity severity in aging research: 4 observational studies in people. The newest story, Nov 11, 2026: “MRI brain-age gap linked to later clinical worsening”.

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1 new paper in 30 daysSee all 7 papers on white matter hyperintensity severity

“Gait speed was slower among those with more severe WMH independent of locomotor risk factors.”

Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain agingJournal of diabetes and its complications2021doi:10.1016/j.jdiacomp.2021.108084

Humans4

Associations

Gait speed

downin humans1

1 study

White matter hyperintensity severity is associated with gait speed in humans (β = -0.22, p = 0.04).
“Gait speed was slower among those with more severe WMH independent of locomotor risk factors.”
HumansChildhood-onset type 1 diabetes; combined model adjusted for diabetes duration and locomotor risk factorsbrain white matter50F/50Msn = 100
Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain aging
Journal of diabetes and its complicationsNov 14, 2021

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3 papers in 12 months

Radiology Artificial IntelligenceNov 11

MRI brain-age gap linked to later clinical worsening

Age estimates differed from actual ages by an average of 3.76 years in internal testing and 4.82–5.15 years in external testing.Age estimates differed from actual ages by an average of 3.76 years in internal testing and 4.82–5.15 years in external testing.

Cohort · 954 peopleBrain age