Unconjugated bilirubin

1. COVID-19 is linked with lower unconjugated bilirubin in humans (hospitalized patients vs healthy controls).

   “UCB levels were significantly lower in individuals with COVID-19, especially in younger COVID-19 patients (p < 0.05).”

   Humanshospitalized patients vs healthy controls

   Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls

   Redox biology·Oct 3, 2023

More on COVID-19

1. Unconjugated bilirubin is associated with chromosomal damage in humans (ρ = 0.21, p = 0.043).

   “Both UCB and telomere length at baseline correlated positively with the number of nucleoplasmatic bridges (NPBs) (ρ = 0.21, p = 0.043 and ρ = 0.41, p = 0.001, respectively) and nuclear buds (NBuds) (ρ = 0.24, p = 0.019 and ρ = 0.51, p = 0.004).”

   Human trialblood6 monthsn = 101

   Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial

   Scientific reports·Dec 1, 2016

2. Unconjugated bilirubin is associated with chromosomal damage in humans (baseline) (p < 0.05).

   “both were associated with increased chromosomal anomalies such as nucleoplasmatic bridges and nuclear buds (p < 0.05).”

   Human trialbaselinen = 101

   Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial

   Scientific reports·Dec 1, 2016

1. Unconjugated bilirubin is associated with telomere length in humans (ρ = 0.238, p = 0.047).

   “In contrast, telomere length and UCB showed a significant correlation at baseline (ρ = 0.238, p = 0.047).”

   Human trialblood6 monthsn = 101

   Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial

   Scientific reports·Dec 1, 2016

2. Unconjugated bilirubin is associated with telomere length in humans (baseline) (p < 0.05).

   “A correlation between UCB and TL was evident at baseline (p < 0.05)”

   Human trialbaselinen = 101

   Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial

   Scientific reports·Dec 1, 2016

More on Telomere length

1. Unconjugated bilirubin is linked with a lower risk of noncommunicable disease in humans.

   “elevated UCB concentrations are linked to a lower risk of developing NCDs”

   Humans

   Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

   iScience·Jun 9, 2024

More on Noncommunicable disease

1. Unconjugated bilirubin is linked with a higher risk of hypertension in humans (HR 1.05 (1.03-1.07)).

   “The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01-1.05) and 1.05 (1.03-1.07)”

   Humansn = 1,881

   The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

   Journal of translational medicine·Mar 4, 2022

More on Hypertension