Tumor-associated macrophages

Biomarker

3 papers study it38 more mention it

MeSH

Animals3

Funding

1 grant since 2020

Food and Drug AdministrationUS$500k

Phase 2 study of combination therapy with PLX3397 and sirolimus to target tumor-associated macrophages in malignant peripheral nerve sheath tumors
Food and Drug AdministrationColumbia University Health SciencesUS$500k2017–2023

Latest

15 papers in 12 months

bioRxivOct 9

Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer

Preprint: computational studyInflammation

Paper

Frontiers in OncologyAug 22

Tumor immunosenescence drives breast cancer progression and therapeutic resistance: mechanisms and emerging interventions

ReviewMechanisms

Paper

Molecular BiomedicineJul 17

Disruption of macrophage migration inhibitory factor signaling induces major tumor-associated macrophage phenotypes in human M2 macrophages

Experiments in human cellscGAS–STING signaling

Paper

bioRxivJul 10

Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling

Preprint: experiments in miceOvarian cancer

Paper

Advanced ScienceMay 21

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor-Associated Macrophages and Potentiates Antitumor Immunity

Experiments in miceBlood and immune system

Paper

Molecular Therapy OncologyMay 1

Nicotinamide mononucleotide enhances anti-tumor effect by resetting macrophages toward the inflammatory M1-like phenotype

Experiments in miceNicotinamide mononucleotide

Paper

Acta Histochemica et CytochemicaApr 30

Aging-Related Morphological Change in Regional Lymph Nodes Promote an Immunosuppressive Microenvironment in Colorectal Cancer

Cohort study of 160 peopleMechanisms

Paper

Cytokine & Growth Factor ReviewsApr 24

Lipid metabolic reprogramming regulates macrophage senescence in the tumor microenvironment

ReviewCellular senescence

Paper

Translational OncologyApr 4

EGR1 lactylation induces tumor cell senescence and immunosuppressive microenvironment in intrahepatic cholangiocarcinoma

Experiments in animalsCellular senescence

Paper

Cellular OncologyMar 23

Targeting senescence-like tumor-associated macrophages sensitizes chemotherapy in triple-negative breast cancer

Experiments in miceTriple-negative breast cancer

Paper