Translational fidelity

Biomarker

1 paper

Cells1

Funding

1 grant since 2020

Natural Sciences and Engineering Research Council of CanadaCA$29.6k

Factors that control translational fidelity in mammalian cells
Natural Sciences and Engineering Research Council of CanadaUniversité de MontréalCA$29.6k2020–2021

Latest

7 in 12 months

bioRxiv29 Sep

Yeast tRNAs show age-associated tail cleavage and modifications

Using direct RNA sequencing in replicatively aging yeast, researchers mapped single-molecule tRNA dynamics, revealing stable total abundance alongside targeted…Using direct RNA sequencing in replicatively aging yeast, researchers mapped single-molecule tRNA dynamics, revealing stable total abundance alongside targeted modifications and 3' CCA-tail cleavage.

Preprint: experiments in yeastAI & data

Paper

bioRxiv26 Sep

Translation error rates rise with age in post-mitotic mouse cells

Mass spectrometry showed error frequencies increased in post-mitotic mouse tissues during aging but not in dividing cells, correlating with changes in tRNA pools.Mass spectrometry showed error frequencies increased in post-mitotic mouse tissues during aging but not in dividing cells, correlating with changes in tRNA pools.

Preprint: experiments in miceMechanisms

Paper

International Journal of Molecular Sciences28 Mar