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VPS70

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 2 more
  • Cells1

Effects

2

Lifespan

upin yeast cells1+8.9% lifespan extension

1 study

  1. VPS70 extends lifespan in yeast cells (~8.9% lifespan extension).

    “Replacing VPS70 in BY by its RM allele reduces translation error by ~8.0% and extends lifespan by ~8.9% through a vacuole-dependent mechanism.”

    CellsReplacing the BY VPS70 allele with its RM allele; vacuole-dependent mechanism

    Translational fidelity and longevity are genetically linked

    Nature communications13 Aug 2025

Translation error

downin yeast cells1−8% reduction

1 study

  1. VPS70 decreases translation error in yeast cells (~8.0% reduction).

    “Replacing VPS70 in BY by its RM allele reduces translation error by ~8.0% and extends lifespan by ~8.9% through a vacuole-dependent mechanism.”

    CellsReplacing the BY VPS70 allele with its RM allele

    Translational fidelity and longevity are genetically linked

    Nature communications13 Aug 2025

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