There are 11 papers on TP53 in aging research: 4 observational studies in people, 5 in animals, 2 in cells.
11 papers study it1 finding
- Humans4
- Animals5
- Cells2
Upstream
1Notch signaling
upin animals1
1 study
Notch signaling
upin animals1
Notch signaling activates TP53 in animals during normal muscle regeneration.
“ligand-dependent stimulation of Notch activates p53 in MuSCs via inhibition of Mdm2 expression through Hey transcription factors during normal muscle regeneration”
Animalsduring normal muscle regenerationskeletal muscle stem cells
Cell stem cell
Funding
3 grants since 2018National Cancer Institute$2.5MNational Institute of Diabetes and Digestive and Kidney Diseases$597K
Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer
National Cancer InstituteUniversity of Washington$517K2021–2026
Statistical methods and tools for cancer risk prediction in families with germline mutations in TP53
National Cancer InstituteUniversity of Tx Md Anderson Can Ctr$352K2019–2024
Early TP53 Mutations and Genomic Doubling as a Novel Path for Barrett's Esophagus Progression
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of California, San Francisco$81.6K2016–2022