1 paper1 finding
Frailty, mild cognitive impairment, and Alzheimer's disease
upin humans1
Frailty, mild cognitive impairment, and Alzheimer's disease is associated with tissue-derived pathway-subset enrichment in blood in humans (23 of 30 predefined pathway-subset tests significantly positively enriched after false-discovery-rate correction).
“23 of 30 predefined tissue-derived pathway-subset tests showed significant positive enrichment after false-discovery-rate correction, whereas individual gene-level bulk-blood associations did not survive correction.”
Humansindependent frailty and ADNI mild cognitive impairment and Alzheimer's disease datasetsperipheral blood
Aging muscle and Alzheimer's brain share inflammatory signals
bioRxiv8 Oct 2026Preprint
Analysing datasets from 23 muscle donors and 30 early-progression brain donors, researchers identified matching inflammatory gene pathways across tissues.Analysing datasets from 23 muscle donors and 30 early-progression brain donors, researchers identified matching inflammatory gene pathways across tissues.