Thromboxane B2

1. PTGS1 mediates thromboxane B2 in humans (β = 5.23, 95% CI 2.33-8.63).

   “Cox-1 partially and significantly mediated the effect of age on TxB2 (β = 5.23, 95% confidence interval [2.33-8.63])”

   Humanseffect of age on TxB2 in atrial fibrillation patientsn = 134

   Age-Related Platelet Cox-1 Upregulation in Atrial Fibrillation

   International journal of molecular sciences·30 May 2026

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1. Age is associated with thromboxane B2 in humans (R = 0.44, p < 0.01).

   “age and TxB2 values (R = 0.44, p-value < 0.01)”

   Humansin patients with atrial fibrillationserumn = 134

   Age-Related Platelet Cox-1 Upregulation in Atrial Fibrillation

   International journal of molecular sciences·30 May 2026

2. Age is associated with thromboxane B2 in humans (R=0.45, +11.6 ng/ml per year).

   “A positive correlation has been found between age and serum TxB2 (R=0.45) with an increase in TxB2 of 11.6 ng/ml per each one-year of age increase.”

   Humanspatients with atrial fibrillation not receiving aspirin

   COX-1 RELATED THROMBOXANE OVERPRODUCTION IN ELDERLY PATIENTS WITH ATRIAL FIBRILLATION

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. PTGS1 is associated with thromboxane B2 in human cells (R=-0.640).

   “a negative correlation between COX-1 expression and platelets’ TxB2 inhibition by ASA (R=-0.640) was found.”

   Cellsin vitro aspirin inhibitionplatelet

   COX-1 RELATED THROMBOXANE OVERPRODUCTION IN ELDERLY PATIENTS WITH ATRIAL FIBRILLATION

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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