Tau tangles

Tau tangles raise the risk of cognitive impairment in humans (HR=2.25, p = 0.0034).

“Cox proportional‐hazard models showed a gradual increase in the risk of clinical progression in the A+T MTL + (HR=2.25, p = 0.0034) and A+T NEO + (HR=3.14, p < 0.0001) groups versus the A+ (reference) group.”

Humansversus A+ group

Prognostic utility of p ‐tau217 and tau PET in Alzheimer's disease

AAIC 2025 abstract·9 Jan 2026

Age at menopause is associated with tau tangles in humans (β=0.070, p = .0002).

“earlier age at menopause exacerbated the associations of reduced synaptic integrity with elevated tau”

Humansinteractive effect with synaptic integrity (complexin-I)brainfemales

The interplay between synaptic integrity and age at menopause on Alzheimer's disease risk in women

AAIC 2025 abstract·23 Dec 2025