Tau protein accumulation
1 paper studies it10 more mention it2 findings
- Humans1
Upstream
2SMS
downin human cells1
1 study
SMS
downin human cells1
SMS decreases Tau protein accumulation in human cells.
“partial loss of SMS by siRNA-mediated knockdown upregulated autophagic flux and reduced Tau protein accumulation.”
Cellsin human neuronal or glial cells
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation
Cell death & diseaseMay 13, 2024
dSms
downin flies1
1 study
dSms
downin flies1
dSms decrease Tau protein accumulation in flies.
“partial loss of dSms enhanced autophagic flux, reduced Tau protein accumulation”
Model organismsin Tauopathy flies
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation
Cell death & diseaseMay 13, 2024
Latest
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Intestinal Organoids from Alzheimer's Disease Transgenic Mice Reveal Structural and Molecular Gut Pathology
Experiments in mouse cellsGut and microbiome
AAIC 2025 Abstract
Head‐to‐head comparison of two senolytic therapies in a mouse model of tauopathy
Experiments in miceSenolytics
Cell Death & Disease
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation
Study in peopleAutophagy
bioRxiv
Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy
Preprint: experiments in fliesAutophagy
The Journal of Prevention of Alzheimer's Disease
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial
Study protocolSenolytics
Journal of Neuroinflammation
Partial reduction of microglia does not affect tau pathology in aged mice
Experiments in animalsInterventions