dSms

1. dSms improve climbing performance in flies.

   “partial loss of dSms enhanced autophagic flux, reduced Tau protein accumulation, and led to extended lifespan and improved climbing performance in Tauopathy flies.”

   Model organismsin Tauopathy flies

   Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

   Cell death & disease·May 13, 2024

2. dSms improve climbing performance in flies.

   “heterozygous dSms flies extends lifespan and improves the climbing performance of flies with human Tau (hTau) overexpression”

   Model organismsin flies with human Tau (hTau) overexpression

   Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy

   bioRxiv : the preprint server for biology·Mar 18, 2023Preprint

1. dSms extend lifespan in flies.

   “partial loss of dSms enhanced autophagic flux, reduced Tau protein accumulation, and led to extended lifespan and improved climbing performance in Tauopathy flies.”

   Model organismsin Tauopathy flies

   Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

   Cell death & disease·May 13, 2024

2. dSms extend lifespan in flies.

   “heterozygous dSms flies extends lifespan and improves the climbing performance of flies with human Tau (hTau) overexpression”

   Model organismsin flies with human Tau (hTau) overexpression

   Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy

   bioRxiv : the preprint server for biology·Mar 18, 2023Preprint

1. dSms decrease Tau protein accumulation in flies.

   “partial loss of dSms enhanced autophagic flux, reduced Tau protein accumulation”

   Model organismsin Tauopathy flies

   Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

   Cell death & disease·May 13, 2024

More on Tau protein accumulation

1. dSms decrease MAPT in flies.

   “heterozygous loss-of-function mutation of dSms reduces hTau protein accumulation through enhancing autophagic flux”

   Model organismsin Drosophila with human Tau overexpression

   Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy

   bioRxiv : the preprint server for biology·Mar 18, 2023Preprint

More on MAPT