HIGH RESOLUTION SPATIAL PROTEOGENOMICS TO ASSESS TARGET ENGAGEMENT AND COMPARE SENOLYTIC EFFICACY IN THE BRAIN OF TAU TRANSGENIC MICE

Abstract

Tau protein accumulation induces cellular senescence in Alzheimer’s disease and other tauopathies contributing to dysfunction and disability. Treating tau transgenic mice with pharmacological agents to clear senescent cells, “senolytics,” reduced brain pathology and improved structure and function.