Spatiotemporal associations between amyloid and tau pathologies in preclinical Alzheimer’s disease

Abstract

Background: In Alzheimer’s disease (AD), the Thal and Braak staging framework describes the typical regional progression of amyloid‐beta (Aβ) and tau, respectively. However, the spatiotemporal relationships between Aβ and tau remain poorly understood. These interactions may influence the rate and pattern of disease progression.