Lower resting‐state phasic locus coeruleus activity is associated with cortical tau accumulation and cognitive decline in preclinical Alzheimer's disease

Abstract

Background: The brainstem noradrenergic locus coeruleus (LC) is among the earliest regions to accumulate Alzheimer's disease (AD)‐related hyperphosphorylated tau. Lower novelty‐related LC activity in older cognitively healthy individuals has been related to greater entorhinal (EC) tau deposition and steeper memory decline.