Phasic locus coeruleus activity

1. Phasic locus coeruleus activity is associated with cognitive function in humans.

   “Lower phasic LC activity was associated with steeper cognitive decline, with larger effect sizes for the memory‐related subtests of PACC5”

   Humansasymptomatic older adultsmean follow-up=5.37±1.88 years

   Lower resting‐state phasic locus coeruleus activity is associated with cortical tau accumulation and cognitive decline in preclinical Alzheimer's disease

   AAIC 2025 abstract·8 Jan 2026

1. Phasic locus coeruleus activity is associated with tau deposition in humans.

   “Lower phasic LC activity was associated with greater baseline EC tau deposition (Figure 2A‐B) and faster medial temporal lobe tau accumulation”

   Humansasymptomatic older adultsentorhinal cortex

   Lower resting‐state phasic locus coeruleus activity is associated with cortical tau accumulation and cognitive decline in preclinical Alzheimer's disease

   AAIC 2025 abstract·8 Jan 2026

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