Papers on T value, newest first

Japanese Journal of OphthalmologyOct 27

Clinical utility of pupil diameter cutoffs for detecting early presbyopia

Cross-sectional study of 115 peopleBiomarkers

Paper

Nutrition ReviewsOct 27

A Supplement Dose Is Not a Nutrient Requirement: When the Same Units Answer Different Questions

CommentaryIndustry & policy

Paper

JMIR Formative ResearchOct 27

Characteristic Facial Expressions During Visual Fixation in Japanese Older Adults With Lower Cognitive Screening Performance: Exploratory Cross-Sectional Study

Cross-sectional study of 31 peopleBiomarkers

Paper

BMC MedicineOct 27

Optimizing precision lung cancer screening using willingness-to-pay–anchored risk eligibility thresholds

Computational studyLung cancer

Paper

Cardiovascular DiabetologyOct 27

Associations of triglyceride-glucose-obesity composite indices with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3 and their potential incremental value beyond a PREVENT-variable-based model

Cohort study of 12,947 peopleCardiovascular-kidney-metabolic syndrome

Paper

Scientific ReportsOct 27

Design and implementation of an automated Drosophila locomotor assay using computer vision tracking

Experiments in fliesAI & data

Paper

Cardiovascular DiabetologyOct 27

Head-to-head comparison of six cumulative metabolic indices and joint association with renal function for incident cardiometabolic multimorbidity in non-diabetic adults with CKM syndrome stages 0–3: a prospective cohort study

Cohort study of 3,788 peopleCardiometabolic multimorbidity

Paper

HealthcareOct 27

Exercise program linked to better physical function in older adults

At 10 weeks, adjusted physical performance scores averaged 9.62 in the program group versus 7.80 in the control group.At 10 weeks, adjusted physical performance scores averaged 9.62 in the program group versus 7.80 in the control group.

Flow of participants through the study (TREND diagram).

Non-randomized trial · 184 peopleInterventions

Paper

Ophthalmology ScienceOct 27

Retinal measurements helped predict cancer in UK cohort

People classified as high risk from retinal measurements had nearly threefold higher cancer risk over 12 years than those classified as low risk.People classified as high risk from retinal measurements had nearly threefold higher cancer risk over 12 years than those classified as low risk.

Cohort · 41,424 peopleCancer

Paper

HealthcareOct 27

Psychological Frailty in Later Life: A Critical Narrative Review of Integrative Interventions and the Proposed RESERVE-7 Heuristic

Proposed formulation model and RESERVE-7 heuristic.

ReviewInterventions

Paper

RadiologyOct 27

Lower bone density on lung scans linked to spine fractures

Over two years, spine fractures occurred in 0.9% of participants with normal bone mass, 2.0% with low bone mass and 5.9% with osteoporosis.Over two years, spine fractures occurred in 0.9% of participants with normal bone mass, 2.0% with low bone mass and 5.9% with osteoporosis.

Cohort · 18,211 peopleVertebral fracture

Paper

HealthcareOct 27

Comprehensive Geriatric Assessment Domains and Routine Inflammatory Indices in Relation to Clinical Frailty Scale-Defined Frailty: A Cross-Sectional Study in Hospital-Based Older Adults

Participant flow. Records were screened for eligibility, and the clinical exclusion criteria (acute infection, active malignancy under treatment, systemic corticosteroid use, ongoing chemotherapy,…

Cross-sectional study of 284 peopleMini Nutritional Assessment

Paper

BiomedicinesOct 27

Choriocapillaris Dysfunction in Retinal Diseases: Multimodal Imaging Biomarkers, Pathophysiological Insights, and Emerging Clinical Applications

The RPE–Bruch’s membrane–choriocapillaris complex and the principal mechanisms of choriocapillaris dysfunction.

ReviewBiomarkers

Paper

BiomedicinesOct 27

Multi-Omics and Digital Biomarkers for Dynamic Cardiometabolic Risk Prediction

Proposed pathway for dynamic molecular–digital risk assessment.

ReviewBiomarkers

Paper

AntioxidantsOct 27

Sulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence

Sulforaphane is abundant in cruciferous vegetables.

ReviewSarcopenia

Paper

AntioxidantsOct 27

Routine Nutritional, Inflammatory, and Redox-Related Biomarker Abnormality Burden Is Associated with Lower 12-Week Physical Performance After Cholecystectomy in Rehabilitation Outpatients

Cohort study of 184 peopleBiomarkers

Paper

BiomedicinesOct 27

Postprocessing of Structural En Face OCT Images of the Choroidal Haller Layer for Quantitative Assessment: An Exploratory Pilot Study

Structural OCT, en face imaging, and artifact masking.

Cross-sectional study of 66 peopleBiomarkers

Paper

AntioxidantsOct 27

Sirtuin-1 in Hypertension: Linking Oxidative Stress and Mitochondrial Dysfunction to Vascular Aging and Therapeutic Potential

Overview of the causes, pathophysiology, cellular alterations, and target-organ damage associated with hypertension.

ReviewSirtuin signaling

Paper

BiomedicinesOct 27

Exploratory Analysis of Age-Associated Somatic Mutation Patterns and Clinicopathologic Features in Endometrial Cancer

Observed-age cutoff scan for gene-level mutation-frequency differences in the TCGA cohort.

Computational studyMechanisms

Paper

BiomoleculesOct 27

Effects of Fixed-Speed Treadmill Exercise on Oxidative Stress and Sirtuin Biomarkers in Young and D-Galactose-Treated Rats: A Biochemical Study with Exploratory Hippocampal Observations

Graph of mean values for MDA and PGC-1α.

Experiments in 64 ratsInterventions

Paper

Diabetes, Obesity, and Cardiometabolic CAREOct 27

Estimating the Health, Economic, and Social Benefits of Obesity Treatment Using Microsimulation Modeling

Computational studyObesity

Paper

Frontiers in ImmunologyOct 27

Integrative single-cell and bulk transcriptomic analysis identifies monocyte/macrophage senescence-associated candidate genes in pulmonary arterial hypertension

Single-cell transcriptomic landscape and cell annotation.

Computational studyCellular senescence

Paper

Frontiers in Aging NeuroscienceOct 27

A clustering approach based on neuropsychological testing to detect early signs of probable MCI among community-dwelling older adults

Individuals grouped by clusters in the three dimensions determined by the principal component analysis and percentage of variance explained by each dimension.

Cross-sectional study of 161 peopleBiomarkers

Paper

Journal of Clinical MedicineOct 27

Hip fracture surgery death rates were higher at 100 and older

Deaths by 12 months reached 80.6% among people aged 100 or older, compared with 30.1% among those aged 65–99 in a retrospective cohort.Deaths by 12 months reached 80.6% among people aged 100 or older, compared with 30.1% among those aged 65–99 in a retrospective cohort.