sRAGE

1. sRAGE is associated with amyloid-beta deposition in humans.

   “sRAGE was associated with reduced Aβ deposition in all regions (p ≤ 0.03)”

   Humanscognitively healthy adultsbrain∼13-15 yearsn = 279

   Mid-life candidate vascular plasma biomarkers are associated with MRI markers of vascular brain injury and amyloid- and tau-PET in cognitively healthy adults

   Journal of Alzheimer's disease : JAD·30 Aug 2026

1. sRAGE is associated with vascular brain injury in humans.

   “soluble receptor for advanced glycation end products (sRAGE) and insulin-like growth factor 1 (IGF-1) were associated with reduced VBI (p ≤ 0.04)”

   Humanscognitively healthy adultsbrain∼13-15 yearsn = 1,039

   Mid-life candidate vascular plasma biomarkers are associated with MRI markers of vascular brain injury and amyloid- and tau-PET in cognitively healthy adults

   Journal of Alzheimer's disease : JAD·30 Aug 2026

1. sRAGE predicts malnutrition in humans (AUC of 0.85).

   “ROC analysis indicated good diagnostic accuracy for identifying malnutrition risk, with an AUC of 0.85.”

   Humansn = 52

   Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET

   Experimental gerontology·10 Jan 2026

More on Malnutrition

1. sRAGE is associated with mini-nutritional assessment short-form in humans (β = -0.001, p = 0.03).

   “poorer nutritional status as revealed by MNA-SF scores (β = -0.001, p = 0.03) at follow-up”

   Humansadjusted for age and sexn = 52

   Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET

   Experimental gerontology·10 Jan 2026

More on Mini-nutritional assessment short-form

1. sRAGE is associated with calf circumference in humans (β = -0.002, p = 0.04).

   “reduced calf circumference (β = -0.002, p = 0.04)”

   Humansadjusted for age and sexn = 52

   Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET

   Experimental gerontology·10 Jan 2026

More on Calf circumference

1. sRAGE is associated with body mass index in humans (β = -0.003, p = 0.036).

   “Higher baseline sRAGE levels were significantly associated with lower BMI (β = -0.003, p = 0.036)”

   Humansadjusted for age and sexn = 52

   Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET

   Experimental gerontology·10 Jan 2026

More on Body mass index